Akinetic‐rigid and tremor‐dominant Parkinson's disease patients show different patterns of FP‐CIT Single photon emission computed tomography
Identifieur interne : 000400 ( Main/Exploration ); précédent : 000399; suivant : 000401Akinetic‐rigid and tremor‐dominant Parkinson's disease patients show different patterns of FP‐CIT Single photon emission computed tomography
Auteurs : Carsten Eggers [Allemagne] ; Deniz Kahraman [Allemagne] ; Gereon R. Fink [Allemagne] ; Matthias Schmidt [Allemagne] ; Lars Timmermann [Allemagne]Source :
- Movement Disorders [ 0885-3185 ] ; 2011-02-15.
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Abstract
Objective:: To elucidate whether Parkinson's disease subtypes show a different pattern of Iodine‐123 fluoropropyl–;carbomethoxy‐3 β‐(FP‐CIT) single photon emission computed tomography (SPECT) binding in accordance with neuropathological findings. Methods:: We analyzed a database of consecutive patients with FP‐CIT scan (n = 190) over a 3‐year period and identified 122 patients (50 women, 72 men, mean age 62 ± 11.1 years) with a diagnosis of idiopathic Parkinson's disease. Patient's characteristics and FP‐CIT scan results were analyzed and compared for the subgroups tremor‐dominant versus akinetic‐rigid and equivalent type of Parkinson's disease. Results:: The analysis of all Parkinson's disease patients showed a significant difference between the FP‐CIT uptake in the subgroups tremor‐dominant and akinetic‐rigid. After matching these samples for age, disease duration, disease severity (Hoehn & Yahr grade, Unified Parkinson's Disease Rating Scale score), and levodopa‐equivalent dose, these findings were balanced between both groups (n = 23/23) without a significant difference (P > 0.05). However, there was a clear, significant association of visually analyzed shapes of the striatum in FP‐CIT SPECT and clinical Parkinson's disease subtype. Conclusion:: These results confirm neuropathological models for a reduced dopaminergic projection to the dorsal putamen in akinetic‐rigid patients as well as the lateral putamen and caudate nucleus in tremor‐dominant patients in vivo. © 2011 Movement Disorder Society
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DOI: 10.1002/mds.23468
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Fink</name></author><author><name sortKey="Schmidt, Matthias" sort="Schmidt, Matthias" uniqKey="Schmidt M" first="Matthias" last="Schmidt">Matthias Schmidt</name></author><author><name sortKey="Timmermann, Lars" sort="Timmermann, Lars" uniqKey="Timmermann L" first="Lars" last="Timmermann">Lars Timmermann</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:EBBE3E5E1AC4717C787ADB46F15F608BF07483DF</idno><date when="2011" year="2011">2011</date><idno type="doi">10.1002/mds.23468</idno><idno type="url">https://api.istex.fr/document/EBBE3E5E1AC4717C787ADB46F15F608BF07483DF/fulltext/pdf</idno><idno type="wicri:Area/Main/Corpus">000D64</idno><idno type="wicri:Area/Main/Curation">000C04</idno><idno type="wicri:Area/Main/Exploration">000400</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Akinetic‐rigid and tremor‐dominant Parkinson's disease patients show different patterns of FP‐CIT Single photon emission computed tomography</title><author><name sortKey="Eggers, Carsten" sort="Eggers, Carsten" uniqKey="Eggers C" first="Carsten" last="Eggers">Carsten Eggers</name><affiliation wicri:level="1"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurology, University of Cologne, Cologne</wicri:regionArea><wicri:noRegion>Cologne</wicri:noRegion><wicri:noRegion>Cologne</wicri:noRegion></affiliation></author><author><name sortKey="Kahraman, Deniz" sort="Kahraman, Deniz" uniqKey="Kahraman D" first="Deniz" last="Kahraman">Deniz Kahraman</name><affiliation wicri:level="1"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Nuclear Medicine, University of Cologne, Cologne</wicri:regionArea><wicri:noRegion>Cologne</wicri:noRegion><wicri:noRegion>Cologne</wicri:noRegion></affiliation></author><author><name sortKey="Fink, Gereon R" sort="Fink, Gereon R" uniqKey="Fink G" first="Gereon R." last="Fink">Gereon R. Fink</name><affiliation wicri:level="1"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurology, University of Cologne, Cologne</wicri:regionArea><wicri:noRegion>Cologne</wicri:noRegion><wicri:noRegion>Cologne</wicri:noRegion></affiliation><affiliation wicri:level="3"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Cognitive Neurology Section, Institute of Neuroscience and Medicine (INM‐3), Research Centre Jülich, Jülich</wicri:regionArea><placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region><region type="district" nuts="2">District de Cologne</region><settlement type="city">Juliers</settlement></placeName></affiliation></author><author><name sortKey="Schmidt, Matthias" sort="Schmidt, Matthias" uniqKey="Schmidt M" first="Matthias" last="Schmidt">Matthias Schmidt</name><affiliation wicri:level="1"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Nuclear Medicine, University of Cologne, Cologne</wicri:regionArea><wicri:noRegion>Cologne</wicri:noRegion><wicri:noRegion>Cologne</wicri:noRegion></affiliation></author><author><name sortKey="Timmermann, Lars" sort="Timmermann, Lars" uniqKey="Timmermann L" first="Lars" last="Timmermann">Lars Timmermann</name><affiliation wicri:level="1"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurology, University of Cologne, Cologne</wicri:regionArea><wicri:noRegion>Cologne</wicri:noRegion><wicri:noRegion>Cologne</wicri:noRegion></affiliation></author></analytic><monogr></monogr><series><title level="j">Movement Disorders</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2011-02-15">2011-02-15</date><biblScope unit="volume">26</biblScope><biblScope unit="issue">3</biblScope><biblScope unit="page" from="416">416</biblScope><biblScope unit="page" to="423">423</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">EBBE3E5E1AC4717C787ADB46F15F608BF07483DF</idno><idno type="DOI">10.1002/mds.23468</idno><idno type="ArticleID">MDS23468</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Iodine‐123 fluoropropyl–carbomethoxy‐3 β‐single photon emission computed tomography</term><term>Parkinson subtype</term><term>Parkinson's disease</term><term>visual analysis</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Objective:: To elucidate whether Parkinson's disease subtypes show a different pattern of Iodine‐123 fluoropropyl–;carbomethoxy‐3 β‐(FP‐CIT) single photon emission computed tomography (SPECT) binding in accordance with neuropathological findings. Methods:: We analyzed a database of consecutive patients with FP‐CIT scan (n = 190) over a 3‐year period and identified 122 patients (50 women, 72 men, mean age 62 ± 11.1 years) with a diagnosis of idiopathic Parkinson's disease. Patient's characteristics and FP‐CIT scan results were analyzed and compared for the subgroups tremor‐dominant versus akinetic‐rigid and equivalent type of Parkinson's disease. Results:: The analysis of all Parkinson's disease patients showed a significant difference between the FP‐CIT uptake in the subgroups tremor‐dominant and akinetic‐rigid. After matching these samples for age, disease duration, disease severity (Hoehn & Yahr grade, Unified Parkinson's Disease Rating Scale score), and levodopa‐equivalent dose, these findings were balanced between both groups (n = 23/23) without a significant difference (P > 0.05). However, there was a clear, significant association of visually analyzed shapes of the striatum in FP‐CIT SPECT and clinical Parkinson's disease subtype. Conclusion:: These results confirm neuropathological models for a reduced dopaminergic projection to the dorsal putamen in akinetic‐rigid patients as well as the lateral putamen and caudate nucleus in tremor‐dominant patients in vivo. © 2011 Movement Disorder Society</div></front></TEI><affiliations><list><country><li>Allemagne</li></country><region><li>District de Cologne</li><li>Rhénanie-du-Nord-Westphalie</li></region><settlement><li>Juliers</li></settlement></list><tree><country name="Allemagne"><noRegion><name sortKey="Eggers, Carsten" sort="Eggers, Carsten" uniqKey="Eggers C" first="Carsten" last="Eggers">Carsten Eggers</name></noRegion><name sortKey="Fink, Gereon R" sort="Fink, Gereon R" uniqKey="Fink G" first="Gereon R." last="Fink">Gereon R. 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